Refeyn Ltd, a leader in mass photometry technology development and distribution for both industry and academia, has introduced a tailored software platform for automatic analysis of substantial mass photometry datasets. This new StreamlineMP software suite offers specialized analysis options, enhancing data processing efficiency with standardized workflows particularly suited for critical bioanalytical usage, promoting consistent and expedited results.
StreamlineMP serves as a complementary, modular add-on to Refeyn’s foundational DiscoverMP software. While DiscoverMP provides versatile and robust analysis tools desired by many, it may present challenges for users needing uniform workflows across extensive datasets. StreamlineMP’s suite of targeted modules assists those users in executing repeated analysis settings on extensive datasets tailored to specific applications, ensuring efficient analysis and homogeneous parameter settings, which manual processing can fail to standardize.
The Antibody Stability Module, the first in the new StreamlineMP suite, efficiently characterizes antibody sample aggregation in bulk significantly faster than manual methods. This purpose-built module offers robust aggregation level statistics for replicate groups. Tailored for large datasets from antibody stability studies, it affords straightforward evaluation of stress conditions or antibody variations. This capability is crucial for tracking aggregation, a pivotal quality attribute for therapeutic antibodies.
Significantly reducing antibody data analysis time by over 80%, the automated StreamlineMP module enhances mass photometry’s rapid, high-resolution, sensitive analysis, providing exceptional insights into antibody aggregation. The Antibody Stability Module facilitates a structured workflow, aggregates replicate measurements for statistical insights, and outputs key aggregation characteristics of the antibodies in samples.
“Identifying our clients’ needs and elevating our mass photometry solutions’ speed and usability, we’re excited to offer StreamlineMP for automated large dataset analysis solutions,” stated Fiona Coats, Refeyn’s chief marketing officer. “Coupled with mass photometry’s advantages as a swift, dependable tool for antibody aggregation analysis, we envision our inaugural software application, the antibody stability module, as an essential asset in therapeutic antibody purity and stability evaluations.”
Demonstrating the new StreamlineMP’s proficient automated aggregation analysis, Refeyn has issued a technology note titled “Quantifying antibody aggregation at nano- and micromolar sample concentrations with the Antibody Stability Module in mass photometry.”
Refeyn’s TwoMP mass photometer and MassFluidix HC rapid dilution accessory work alongside the Antibody Stability Module to efficiently gauge aggregation in various antibody standards. The latest tech note highlights the streamlined, swift quantification of antibody aggregation through mass photometry empowered by the new stability module.